Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells.

ABSTRACT:

Rationale

Misregulation of angiotensin II (Ang II) actions can lead to atherosclerosis and hypertension. Evaluating transcriptomic responses to Ang II in vascular smooth muscle cells (VSMCs) is important to understand the gene networks regulated by Ang II, which might uncover previously unidentified mechanisms and new therapeutic targets.

Objective

To identify all transcripts, including novel protein-coding and long noncoding RNAs, differentially expressed in response to Ang II in rat VSMCs using transcriptome and epigenome profiling.

Methods and results

De novo assembly of transcripts from RNA-sequencing revealed novel protein-coding and long noncoding RNAs (lncRNAs). The majority of the genomic loci of these novel transcripts are enriched for histone H3 lysine-4-tri

SUBMITTER: Leung A 

PROVIDER: S-EPMC3763837 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature