Development of a chimeric c-Src kinase and HDAC inhibitor.

ABSTRACT: On the basis of synergism observed between a selective c-Src kinase inhibitor with an HDAC inhibitor, the development of the first chimeric c-Src kinase and HDAC inhibitor is described. The optimized chimeric inhibitor is shown to be a potent c-Src and HDAC inhibitor. Chimeric inhibitor 4 is further shown to be highly efficacious in cancer cell lines and significantly more efficacious than a dual-targeting strategy using discrete c-Src and HDAC inhibitors.

SUBMITTER: Ko KS 

PROVIDER: S-EPMC3763859 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature