Effect of cerium oxide nanoparticles on intestinal serotonin in zebrafish.

ABSTRACT: Cerium oxide nanoparticles or nanoceria are emerging as a new and promising class of nanoparticle technology for biomedical applications. The safe implementation of these particles in clinical applications requires evaluation of their redox properties and reactivity that might cause neurotoxic effects by interacting with redox components of the physiological environment. We report in vitro and in vivo studies to evaluate the impact of nanoceria exposure on serotonin (5-HT), an important neurotransmitter that plays a critical role in various physiological processes including motility and secretion in the digestive system. In vitro studies of 5-HT in the presence of nanoceria using spectroscopic, electrochemical and surface characterization methods demonstrate that nanoc

SUBMITTER: Ozel RE 

PROVIDER: S-EPMC3763867 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature