ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration.

ABSTRACT:

Purpose

To determine if genetic variants that have been associated with age-related macular degeneration (AMD) have a differential effect on the risk of choroidal neovascularization (CNV) and geographic atrophy.

Design

Genetic association study.

Methods

Setting

Multicenter study.

Study population

Seven hundred forty-nine participants with geographic atrophy and 3209 participants with CNV were derived from 4 AMD studies with similar procedures from Tufts Medical Center, the Age-Related Eye Disease Study, University of Utah, and Hopital Intercommunal de Creteil.

Procedures

AMD grade was assigned based on fundus photography and examination using the clinical age-related maculopathy staging system. All samples were genotyped for single nucleotide pol

SUBMITTER: Sobrin L 

PROVIDER: S-EPMC3763907 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature