Synthesis of 6-Se-guanosine RNAs for structural study.

ABSTRACT: 6-Se-guanosine phosphoramidite and RNAs have been synthesized by selenium substitution of the 6-oxygen atom, and it is revealed that the Se-derivatization is relatively stable and that bulge and wobble structures can better accommodate a large Se atom than a duplex. This Se-modification is useful in the structural study of RNAs and their protein complexes.

SUBMITTER: Salon J 

PROVIDER: S-EPMC3763942 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature