Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder.

ABSTRACT:

Objective

Attention-deficit/hyperactivity disorder (ADHD) has been linked to deficits in the dopaminergic reward-processing circuitry; yet, existing evidence is limited, and the influence of genetic variation affecting dopamine signaling remains unknown. We investigated striatal responsivity to rewards in ADHD combined type (ADHD-CT) using functional magnetic resonance imaging (fMRI), and whether it is modulated by variation in the dopamine transporter gene (DAT1).

Method

We tested 29 male adolescents with ADHD-CT and 30 age-, handedness-, and gender-matched healthy controls who were selected for DAT1(10/6) haplotype dosage. Based on previous research, we focused our analysis on the ventral striatum and the caudate nucleus.

Results

Three main findings emerged. First,

SUBMITTER: Paloyelis Y 

PROVIDER: S-EPMC3763946 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature