Macrophage gene expression in adipose tissue is associated with insulin sensitivity and serum lipid levels independent of obesity.

ABSTRACT:

Objective

Obesity is linked to both increased metabolic disturbances and increased adipose tissue macrophage infiltration. However, whether macrophage infiltration directly influences human metabolism is unclear. The aim of this study was to investigate if there are obesity-independent links between adipose tissue macrophages and metabolic disturbances.

Design and methods

Expression of macrophage markers in adipose tissue was analyzed by DNA microarrays in the SOS Sib Pair study and in patients with type 2 diabetes and a BMI-matched healthy control group.

Results

The expression of macrophage markers in adipose tissue was increased in obesity and associated with several metabolic and anthropometric measurements. After adjustment for BMI, the expression remained associa

SUBMITTER: Ahlin S 

PROVIDER: S-EPMC3763968 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature