Preoperative endogenous ouabain predicts acute kidney injury in cardiac surgery patients.

ABSTRACT:

Objectives

Acute kidney injury is a frequent complication of cardiac surgery and increases morbidity and mortality. As preoperative biomarkers predicting the development of acute kidney injury are not available, we have tested the hypothesis that preoperative plasma levels of endogenous ouabain may function as this type of biomarker.

Rationale and design

Endogenous ouabain is an adrenal stress hormone associated with adverse cardiovascular outcomes. Its involvement in acute kidney injury is unknown. With studies in patients and animal settings, including isolated podocytes, we tested the above mentioned hypothesis.

Patients

Preoperative endogenous ouabain was measured in 407 patients admitted for elective cardiac surgery and in a validation population of 219 other pat

SUBMITTER: Bignami E 

PROVIDER: S-EPMC3763989 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature