Identification of a novel and unique transcription factor in the intraerythrocytic stage of Plasmodium falciparum.

ABSTRACT: The mechanisms of stage-specific gene regulation in the malaria parasite Plasmodium falciparum are largely unclear, with only a small number of specific regulatory transcription factors (AP2 family) having been identified. In particular, the transcription factors that function in the intraerythrocytic stage remain to be elucidated. Previously, as a model case for stage-specific transcription in the P. falciparum intraerythrocytic stage, we analyzed the transcriptional regulation of pf1-cys-prx, a trophozoite/schizont-specific gene, and suggested that some nuclear factors bind specifically to the cis-element of pf1-cys-prx and enhance transcription. In the present study, we purified nuclear factors from parasite nuclear extract by 5 steps of chromatography, and identified a factor termed PR

SUBMITTER: Komaki-Yasuda K 

PROVIDER: S-EPMC3764013 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature