Identification of immune and viral correlates of norovirus protective immunity through comparative study of intra-cluster norovirus strains.

ABSTRACT: Whether or not primary norovirus infections induce protective immunity has become a controversial issue, potentially confounded by the comparison of data from genetically distinct norovirus strains. Early human volunteer studies performed with a norovirus-positive inoculum initially led to the conclusion that primary infection does not generate long-term, protective immunity. More recently though, the epidemiological pattern of norovirus pandemics has led to the extrapolation that primary norovirus infection induces herd immunity. While these are seemingly discordant observations, they may in fact reflect virus strain-, cluster-, or genogroup-specific differences in protective immunity induction. Here, we report that highly genetically related intra-cluster murine norovirus strains differ

SUBMITTER: Zhu S 

PROVIDER: S-EPMC3764223 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature