Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke.

ABSTRACT: Although ischemic stroke is a major cause of morbidity and mortality, current therapies benefit only a small proportion of patients. Transplantation of mesenchymal stromal cells (MSC, also known as mesenchymal stem cells or multipotent stromal cells) has attracted attention as a regenerative therapy for numerous diseases, including stroke. Mesenchymal stromal cells may aid in reducing the long-term impact of stroke via multiple mechanisms that include induction of angiogenesis, promotion of neurogenesis, prevention of apoptosis, and immunomodulation. In this review, we discuss the clinical rationale of MSC for stroke therapy in the context of their emerging utility in other diseases, and their recent clinical approval for treatment of graft-versus-host disease. An analysis of preclinical s

SUBMITTER: Eckert MA 

PROVIDER: S-EPMC3764389 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature