Ontology highlight
ABSTRACT:
SUBMITTER: Turek FW
PROVIDER: S-EPMC3764501 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20050421 5724
The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was at ...[more]