Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats.

ABSTRACT:

Background and purpose

Anti-histaminergic drugs have been widely used in the clinical treatment of vestibular disorders and most studies concentrate on their presynaptic actions. The present study investigated the postsynaptic effect of histamine on medial vestibular nucleus (MVN) neurons and the underlying mechanisms.

Experimental approach

Histamine-induced postsynaptic actions on MVN neurons and the corresponding receptor and ionic mechanisms were detected by whole-cell patch-clamp recordings on rat brain slices. The distribution of postsynaptic histamine H₁, H₂ and H₄ receptors was mapped by double and single immunostaining. Furthermore, the expression of mRNAs for H₁, H₂ and H₄ receptors and for subtypes of Na⁺ -Ca²⁺ exchangers (NCXs) and hyperpolarization-activated cycl

SUBMITTER: Zhang XY 

PROVIDER: S-EPMC3764857 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature