Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial.

ABSTRACT:

Background

Growth hormone–releasing hormone(GHRH), growth hormone, and insulin like growth factor 1 have potent effects on brain function, their levels decrease with advancing age, and they likely play a role in the pathogenesis of Alzheimer disease. Previously, we reported favorable cognitive effects of short-term GHRH administration in healthy older adults and provided preliminary evidence to suggest a similar benefit in adults with mild cognitive impairment (MCI).

Objective

To examine the effects of GHRH on cognitive function in healthy older adults and in adults with MCI.

Design

Randomized,double-blind,placebo-controlled trial.

Setting

Clinical Research Center, University of Washington School of Medicine in Seattle.

Participants

A total of 152 adults

SUBMITTER: Baker LD 

PROVIDER: S-EPMC3764914 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature