Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging.

ABSTRACT:

Importance

Growth hormone-releasing hormone (GHRH) has been previously shown to have cognition-enhancing effects. The role of neurotransmitter changes, measured by proton magnetic resonance spectroscopy, may inform the mechanisms for this response.

Objective

To examine the neurochemical effects of GHRH in a subset of participants from the parent trial.

Design

Randomized, double-blind, placebo-controlled substudy of a larger trial.

Setting

Clinical research unit at the University of Washington School of Medicine.

Participants

Thirty adults (17 with mild cognitive impairment [MCI]), ranging in age from 55 to 87 years, were enrolled and successfully completed the study.

Interventions

Participants self-administered daily subcutaneous injections of tes

SUBMITTER: Friedman SD 

PROVIDER: S-EPMC3764915 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature