Common rs7138803 variant of FAIM2 and obesity in Han Chinese.

ABSTRACT:

Background

Obesity causes severe healthcare problem worldwide leading to numerous diseases, such as cardiovascular diseases and diabetes mellitus. Previous Genome-Wide Association Study (GWAS) identified an association between a single nucleotide polymorphism (SNP) rs7138803, on chromosome 12q13 and obesity in European Caucasians. Since the genetic architecture governing the obesity may vary among different populations, we investigate the variant rs7138803 in Chinese population to find out whether it is associated with obesity.

Methods

A population-based cohort association study was carried out using the High Resolution Melt (HRM) method with 1851 participants. The association between rs7138803 genotypes and body mass index (BMI) was modeled with a general linear model, and

SUBMITTER: Li C 

PROVIDER: S-EPMC3765134 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature