Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses.

ABSTRACT:

Background

The development of an effective AIDS vaccine has been a formidable task, but remains a critical necessity. The well conserved membrane-proximal external region (MPER) of the HIV-1 gp41 glycoprotein is one of the crucial targets for AIDS vaccine development, as it has the necessary attribute of being able to elicit antibodies capable of neutralizing diverse isolates of HIV.

Methodology/principle findings

Guided by X-ray crystallography, molecular modeling, combinatorial chemistry, and powerful selection techniques, we designed and produced six combinatorial libraries of chimeric human rhinoviruses (HRV) displaying the MPER epitopes corresponding to mAbs 2F5, 4E10, and/or Z13e1, connected to an immunogenic surface loop of HRV via linkers of varying lengths and seque

SUBMITTER: Yi G 

PROVIDER: S-EPMC3765159 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature