Metabolic perturbations of kidney and spleen in murine cerebral malaria: (1)H NMR-based metabolomic study.

ABSTRACT: A significant fraction of global population is under the threat of malaria. Majority of annual death is due to the more complicated form of the infection i.e. the cerebral form, also known as Cerebral Malaria (CM). Host parasite interaction is known to cause a cascade of events in various tissues like brain, liver, kidney, and spleen. We have employed (1)H NMR based metabolomics to understand the specific perturbations of various tissues in CM. In our previous paper we have delineated the differences between CM vis-a-vis non-cerebral malaria (NCM) mice in serum, liver and brain. In this paper we focus on their differences of metabolic profile in kidney and spleen as kidney dysfunction and splenomegaly are known to be associated to neurological outcome of the disease. Moreover we have also

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC3765208 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature