Proteomic analysis of extremely severe hand, foot and mouth disease infected by enterovirus 71.

ABSTRACT:

Background

To clarify the molecular mechanisms that participate in the severe hand, foot and mouth disease (HFMD) infected by Enterovirus 71 and to detect any related protein biomarkers, we performed proteomic analysis of protein extracts from 5 extremely severe HFMD children and 5 healthy children.

Methods

The protein profiles of them were compared using two-dimensional electrophoresis. Differentially expressed proteins were identified using mass spectrometry. Functional classifications of these proteins were based on the PANTHER. The interaction network of the differentially expressed protein was generated with Pathway Studio.

Results

A total of 38 differentially expressed proteins were identified. Functional classifications of these proteins indicated a series of a

SUBMITTER: Deng L 

PROVIDER: S-EPMC3765220 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature