Human growth is associated with distinct patterns of gene expression in evolutionarily conserved networks.

ABSTRACT:

Background

A co-ordinated tissue-independent gene expression profile associated with growth is present in rodent models and this is hypothesised to extend to all mammals. Growth in humans has similarities to other mammals but the return to active long bone growth in the pubertal growth spurt is a distinctly human growth event. The aim of this study was to describe gene expression and biological pathways associated with stages of growth in children and to assess tissue-independent expression patterns in relation to human growth.

Results

We conducted gene expression analysis on a library of datasets from normal children with age annotation, collated from the NCBI Gene Expression Omnibus (GEO) and EBI Arrayexpress databases. A primary data set was generated using cells of lymph

SUBMITTER: Stevens A 

PROVIDER: S-EPMC3765282 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature