Improved leptin sensitivity as a potential candidate responsible for the spontaneous food restriction of the Lou/C rat.

ABSTRACT: The Lou/C rat, an inbred strain of Wistar origin, was described as a model of resistance to age- and diet-induced obesity. Although such a resistance involves many metabolic parameters described in our previous studies, Lou/C rats also exhibit a spontaneous food restriction due to decreased food consumption during the nocturnal period. We then attempted to delineate the leptin sensitivity and mechanisms implicated in this strain, using different protocols of acute central and peripheral leptin administration. A first analysis of the meal patterns revealed that Lou/C rats eat smaller meals, without any change in meal number compared to age-matched Wistar animals. Although the expression of the recognized leptin transporters (leptin receptors and megalin) measured in the choroid plexus was n

SUBMITTER: Veyrat-Durebex C 

PROVIDER: S-EPMC3765307 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature