Association between 5p12 genomic markers and breast cancer susceptibility: evidence from 19 case-control studies.

ABSTRACT:

Background

The association between polymorphisms on 5p12 and breast cancer (BC) has been widely evaluated since it was first identified through genome-wide association approach; however, the studies have yielded contradictory results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on two wildly studied polymorphisms (rs10941679 and rs4415084) on 5p12.

Methods

Databases including Pubmed, EMBASE, Web of Science, EBSCO, and Cochrane Library databases were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias.

Results

A total of 19 articles involving 100,083 cases an

SUBMITTER: Wang X 

PROVIDER: S-EPMC3765311 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature