IBC CARe microarray allelic population prevalences in an American Indian population.

ABSTRACT:

Background

The prevalence of variant alleles among single nucleotide polymorphisms (SNPs) is not well known for many minority populations. These population allele frequencies (PAFs) are necessary to guide genetic epidemiology studies and to understand the population specific contribution of these variants to disease risk. Large differences in PAF among certain functional groups of genes could also indicate possible selection pressure or founder effects of interest. The 50K SNP, custom genotyping microarray (CARe) was developed, focusing on about 2,000 candidate genes and pathways with demonstrated pathophysiologic influence on cardiovascular disease (CVD).

Methods

The CARe microarray was used to genotype 216 unaffected controls in a study of pre-eclampsia among a Northern Pl

SUBMITTER: Best LG 

PROVIDER: S-EPMC3765406 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature