The effect of simvastatin on lipid droplets accumulation in human embryonic kidney cells and pancreatic cancer cells.

ABSTRACT:

Background

Statins (HMG-CoA reductase inhibitors) represent a major class of compounds for the treatment of hypercholesterolemia due to their ability to inhibit de novo cholesterol synthesis. In addition to their hypolipidemic effects, chemoprotective properties have been attributed to statins as well. These effects involve multiple mechanisms, which, however, are not known in detail. The aim of our study was to assess in non-malignant as well as cancer cells the impact of simvastatin on the amount of cytosolic lipid droplets (LDs) implicated in many biological processes including proliferation, inflammation, carcinogenesis, apoptosis, necrosis or growth arrest.

Methods

Human embryonic kidney cells HEK-293T and human pancreatic cancer cells MiaPaCa-2 were treated with simvas

SUBMITTER: Gbelcova H 

PROVIDER: S-EPMC3765626 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature