Modulation of cardiometabolic pathways in skin and serum from patients with psoriasis.

ABSTRACT:

Background

Moderate-to-severe psoriasis is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD); however, the link is poorly understood.

Methods

Skin and serum from patients with psoriasis were evaluated to understand if there was evidence of dysregulation in a targeted group of inflammatory and lipid genes related to ASCVD. Microarray analyses of expression of targeted ASCVD genes from skin in 89 patients with moderate-to-severe psoriasis from the ACCEPT trial were compared with non-diseased skin from healthy controls (n = 25). Serum (n = 149) was tested at baseline for monocyte chemoattractant protein-1 (MCP-1), macrophage-derived chemokine (MDC), and apolipoprotein-A1 (Apo-A1) comparing to healthy controls (n=162).

Results

An increase

SUBMITTER: Mehta NN 

PROVIDER: S-EPMC3765699 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature