Comparative genomics of Campylobacter concisus isolates reveals genetic diversity and provides insights into disease association.

ABSTRACT:

Background

In spite of its association with gastroenteritis and inflammatory bowel diseases, the isolation of Campylobacter concisus from both diseased and healthy individuals has led to controversy regarding its role as an intestinal pathogen. One proposed reason for this is the presence of high genetic diversity among the genomes of C. concisus strains.

Results

In this study the genomes of six C. concisus strains were sequenced, assembled and annotated including two strains isolated from Crohn's disease patients (UNSW2 and UNSW3), three from gastroenteritis patients (UNSW1, UNSWCS and ATCC 51562) and one from a healthy individual (ATCC 51561). The genomes of C. concisus BAA-1457 and UNSWCD, available from NCBI, were included in subsequent comparative genomic analyses. The

SUBMITTER: Deshpande NP 

PROVIDER: S-EPMC3765806 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature