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Associations of genetic polymorphisms of SAA1 with cerebral infarction.

ABSTRACT:

Background

Serum amyloid A protein (SAA) is both an inflammatory factor and an apolipoprotein. However, the relation between genetic polymorphisms of SAA and cerebral infarction (CI) remains unclear.

Methods and results

The previously reported 4 Single Nucleotide Polymorphisms (rs12218, rs4638289, rs7131332, and rs11603089) of SAA1 gene were genotyped by TaqMan method in a case-control study including 287 cerebral infarction patients and 376 control subjects. We found rs12218 CC genotype and rs7131332 AA genotype were more frequent among CI patients than among controls (9.76% versus 3.19%, P = 0.001; 32.75% versus 24.20%; p = 0.017; respectively). After adjustment of confounding factors such as sex, age, smoking, drinking, hypertension, diabetes, and lipids profile, the difference remained significant in rs12218 (P < 0.01, OR = 2.106, 95% CI: 1.811-7.121).

Conclusion

Genetic polymorphism of SAA1 may be a genetic maker of cerebral infarction in Chinese.

SUBMITTER: Zhang LJ

PROVIDER: S-EPMC3765816 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Associations of genetic polymorphisms of SAA1 with cerebral infarction.

Zhang Li-Jun LJ Yuan Bin B Li He-Hua HH Tao Sheng-Bo SB Yan Hai-Qing HQ Chang Li L Zhao Jian-Hua JH

Lipids in health and disease 20130829

<h4>Background</h4>Serum amyloid A protein (SAA) is both an inflammatory factor and an apolipoprotein. However, the relation between genetic polymorphisms of SAA and cerebral infarction (CI) remains unclear.<h4>Methods and results</h4>The previously reported 4 Single Nucleotide Polymorphisms (rs12218, rs4638289, rs7131332, and rs11603089) of SAA1 gene were genotyped by TaqMan method in a case-control study including 287 cerebral infarction patients and 376 control subjects. We found rs12218 CC g ...[more]

PMID: 23987125

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