Systematic review of genome-wide gene expression studies of bipolar disorder.

ABSTRACT:

Background

Numerous genome-wide gene expression studies of bipolar disorder (BP) have been carried out. These studies are heterogeneous, underpowered and use overlapping samples. We conducted a systematic review of these studies to synthesize the current findings.

Methods

We identified all genome-wide gene expression studies on BP in humans. We then carried out a quantitative mega-analysis of studies done with post-mortem brain tissue. We obtained raw data from each study and used standardized procedures to process and analyze the data. We then combined the data and conducted three separate mega-analyses on samples from 1) any region of the brain (9 studies); 2) the prefrontal cortex (PFC) (6 studies); and 3) the hippocampus (2 studies). To minimize heterogeneity across stud

SUBMITTER: Seifuddin F 

PROVIDER: S-EPMC3765828 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature