Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism.

ABSTRACT:

Background

Autism is a pervasive neurodevelopmental disorder. At present there are no defined mechanisms of pathogenesis and therapy is mostly limited to behavioral interventions. Stem cell transplantation may offer a unique treatment strategy for autism due to immune and neural dysregulation observed in this disease. This non-randomized, open-label, single center phase I/II trial investigated the safety and efficacy of combined transplantation of human cord blood mononuclear cells (CBMNCs) and umbilical cord-derived mesenchymal stem cells (UCMSCs) in treating children with autism.

Methods

37 subjects diagnosed with autism were enrolled into this study and divided into three groups: CBMNC group (14 subjects, received CBMNC transplantation and rehabilitation therapy), Combina

SUBMITTER: Lv YT 

PROVIDER: S-EPMC3765833 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature