Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country.

ABSTRACT:

Background

This study describes chronic kidney disease of uncertain aetiology (CKDu), which cannot be attributed to diabetes, hypertension or other known aetiologies, that has emerged in the North Central region of Sri Lanka.

Methods

A cross-sectional study was conducted, to determine the prevalence of and risk factors for CKDu. Arsenic, cadmium, lead, selenium, pesticides and other elements were analysed in biological samples from individuals with CKDu and compared with age- and sex-matched controls in the endemic and non-endemic areas. Food, water, soil and agrochemicals from both areas were analysed for heavy metals.

Results

The age-standardised prevalence of CKDu was 12.9% (95% confidence interval [CI] = 11.5% to 14.4%) in males and 16.9% (95% CI = 15.5% to 18.3%)

SUBMITTER: Jayatilake N 

PROVIDER: S-EPMC3765913 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature