Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system.

ABSTRACT:

Background

The RNA-binding protein tristetraprolin (TTP) participates in normal post-transcriptional control of cytokine and chemokine gene expression, dysregulation of which contributes to the HIV-associated neurocognitive disorders. Transcriptional and post-transcriptional regulation of TTP has been described, including regulation by microRNA-29a. In the simian immunodeficiency virus (SIV) model of HIV CNS disease, control of cytokine/chemokine expression coincides with the end of acute phase infection. This control is lost during progression to disease. In this study, we assessed TTP regulation and association with cytokine regulation in the brain during SIV infection.

Results

Quantitation of TTP expression over the course of SIV infection revealed downregulation of TTP d

SUBMITTER: Liu J 

PROVIDER: S-EPMC3766027 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature