Comparative genomics of metabolic capacities of regulons controlled by cis-regulatory RNA motifs in bacteria.

ABSTRACT:

Background

In silico comparative genomics approaches have been efficiently used for functional prediction and reconstruction of metabolic and regulatory networks. Riboswitches are metabolite-sensing structures often found in bacterial mRNA leaders controlling gene expression on transcriptional or translational levels.An increasing number of riboswitches and other cis-regulatory RNAs have been recently classified into numerous RNA families in the Rfam database. High conservation of these RNA motifs provides a unique advantage for their genomic identification and comparative analysis.

Results

A comparative genomics approach implemented in the RegPredict tool was used for reconstruction and functional annotation of regulons controlled by RNAs from 43 Rfam families in diverse ta

SUBMITTER: Sun EI 

PROVIDER: S-EPMC3766115 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature