MicroRNAs expression profiling of eutopic proliferative endometrium in women with ovarian endometriosis.

ABSTRACT:

Background

The eutopic endometrium of women with endometriosis, compared with disease-free individuals, contains certain molecular alterations, including the differential expression of microRNA (miRNA). The aim of the study was to compare the expression of the most relevant miRNAs in the eutopic endometrium of women with and without ovarian endometriosis.

Methods

A total of 46 regularly menstruating patients, 21 patients with ovarian endometriosis and 25 controls, underwent surgery in the proliferative phase of the cycle. The eutopic endometrium was collected through aspirating biopsy prior to laparoscopy. Only patients with advanced (stage III and IV) histopathologically confirmed ovarian endometriosis were included. TaqMan MicroRNA Array Cards were applied to examine the e

SUBMITTER: Laudanski P 

PROVIDER: S-EPMC3766175 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature