Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.

ABSTRACT: Neurons and other cells require intracellular transport of essential components for viability and function. Previous work has shown that while net amyloid precursor protein (APP) transport is generally anterograde, individual vesicles containing APP move bi-directionally. This discrepancy highlights our poor understanding of the in vivo regulation of APP-vesicle transport. Here, we show that reduction of presenilin (PS) or suppression of gamma-secretase activity substantially increases anterograde and retrograde velocities for APP vesicles. Strikingly, PS deficiency has no effect on an unrelated cargo vesicle class containing synaptotagmin, which is powered by a different kinesin motor. Increased velocities caused by PS or gamma-secretase reduction require functional kinesin-1 and dynein m

SUBMITTER: Gunawardena S 

PROVIDER: S-EPMC3766177 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature