Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia.

ABSTRACT:

Background

Small nucleolar RNAs (snoRNAs) and small Cajal body-specific RNAs are non-coding RNAs involved in the maturation of other RNA molecules. Alterations of sno/scaRNA expression may play a role in cancerogenesis. This study elucidates the patterns of sno/scaRNA expression in 211 chronic lymphocytic leukemia (CLL) patients (Binet stage A) also in comparison with those of different normal B-cell subsets.

Methods

The patterns of sno/scaRNA expression in highly purified CD19+ B-cells of 211 CLL patients and in 18 normal B-cell samples--6 from peripheral blood, and 12 from tonsils (4 germinal center, 2 marginal zone, 3 switched memory and 3 naïve B-cells)--were analyzed on the Affymetrix GeneChip® Human Gene 1.0 ST array.

Results

CLLs display a sno/scaRNAs expressio

SUBMITTER: Ronchetti D 

PROVIDER: S-EPMC3766210 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature