A structural comparison of lipopolysaccharide biosynthesis loci of Legionella pneumophila serogroup 1 strains.

ABSTRACT:

Background

The lipopolysaccharide (LPS) is the major immuno-dominant antigen of all Legionella species including L. pneumophila. Its diversity is the basis for the classification of L. pneumophila into serogroups and monoclonal subgroups and is thought to be involved in strain specific virulence. The understanding of the genetic basis of the LPS-antigen is incomplete. Thus, we analyzed the genetic locus involved in LPS-biosynthesis of L. pneumophila serogroup 1 (Sg1) strains with the focus on strain specific gene composition.

Results

The LPS-biosynthesis loci of 14 L. pneumophila Sg1 strains comprise two distinct regions: A 15 kb region containing LPS-biosynthesis genes that can be found in all L. pneumophila strains and a Sg1-specific 18 kb region. The 15 kb region is highl

SUBMITTER: Petzold M 

PROVIDER: S-EPMC3766260 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature