Exploration of freely available web-interfaces for comparative homology modelling of microbial proteins.

ABSTRACT:

Aim

This study was conducted to find the best suited freely available software for modelling of proteins by taking a few sample proteins. The proteins used were small to big in size with available crystal structures for the purpose of benchmarking. Key players like Phyre2, Swiss-Model, CPHmodels-3.0, Homer, (PS)2, (PS)(2)-V(2), Modweb were used for the comparison and model generation.

Results

Benchmarking process was done for four proteins, Icl, InhA, and KatG of Mycobacterium tuberculosis and RpoB of Thermus Thermophilus to get the most suited software. Parameters compared during analysis gave relatively better values for Phyre2 and Swiss-Model.

Conclusion

This comparative study gave the information that Phyre2 and Swiss-Model make good models of small and large prot

SUBMITTER: Nema V 

PROVIDER: S-EPMC3766314 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature