Histone deacetylase inhibitors and epigenetic modifications as a novel strategy in renal cell carcinoma.

ABSTRACT: Recent investigations of renal cell carcinoma (RCC) have revealed several epigenetic modifications, as well as alterations in the genes and enzymes that regulate these changes. Preclinical models have revealed that histone gene modifiers and epigenetic alterations may play a critical role in RCC tumorigenesis. Specific changes in DNA methylation and mutations of histone modifiers have been identified and may be associated with an aggressive phenotype. In addition, the potential of reversing the effects of these enzymes and hence reversing the cellular epigenetic landscape to a "normal phenotype" have led to an increasing interest in developing targeted chromatin remodeling agents. However, the translation of the understanding of these changes to the clinic for the treatment of RCC has pose

SUBMITTER: Ramakrishnan S 

PROVIDER: S-EPMC3766322 | biostudies-literature | 2013 Jul-Aug

REPOSITORIES: biostudies-literature