A cohort study evaluation of maternal PCB exposure related to time to pregnancy in daughters.

ABSTRACT:

Background

Polychlorinated biphenyls (PCBs) remain ubiquitous environmental contaminants. Developmental exposures are suspected to impact reproduction. Analysis of mixtures of PCBs may be problematic as components have a complex correlation structure, and along with limited sample sizes, standard regression strategies are problematic. We compared the results of a novel, empirical method to those based on categorization of PCB compounds by (1) hypothesized biological activity previously proposed and widely applied, and (2) degree of ortho- substitution (mono, di, tri), in a study of the relation of maternal serum PCBs and daughter's time to pregnancy.

Methods

We measured PCBs in maternal serum samples collected in the early postpartum in 289 daughters in the Child Health and

SUBMITTER: Gennings C 

PROVIDER: S-EPMC3766643 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature