Efficient production of l-lactic acid by an engineered Thermoanaerobacterium aotearoense with broad substrate specificity.

ABSTRACT:

Background

Efficient conversion of lignocellulosic biomass to optically pure lactic acid is a key challenge for the economical production of biodegradable poly-lactic acid. A recently isolated strain, Thermoanaerobacterium aotearoense SCUT27, is promising as an efficient lactic acid production bacterium from biomass due to its broad substrate specificity. Additionally, its strictly anaerobic and thermophilic characteristics suppress contamination from other microoragnisms. Herein, we report the significant improvements of concentration and yield in lactic acid production from various lignocellulosic derived sugars, achieved by the carbon flux redirection through homologous recombination in T. aotearoense SCUT27.

Results

T. aotearoense SCUT27 was engineered to block the aceti

SUBMITTER: Yang X 

PROVIDER: S-EPMC3766646 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature