Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR-127 in human bladder cancer.

ABSTRACT:

Background

Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs) that have critical roles in the regulation of gene expression.In this study, we aimed to predict potential mechanisms of bladder cancer related miRNAs and target genes by bioinformatics analyses.

Methods

Here we used the method of text mining to identify nine miRNAs in bladder cancer and adopted protein-protein interaction analysis to identify interaction sites between these miRNAs and related-target genes.

Results

There are two relationship types between bladder cancer and its related miRNAs: causal and unspecified. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment test showed

SUBMITTER: Xu Y 

PROVIDER: S-EPMC3766679 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature