Autologous haematopoietic cell transplantation for non-Hodgkin lymphoma with secondary CNS involvement.

ABSTRACT: Pre-existing central nervous system (CNS) involvement may influence referral for autologous haematopoietic cell transplantation (AHCT) for patients with non-Hodgkin lymphoma (NHL). The outcomes of 151 adult patients with NHL with prior secondary CNS involvement (CNS(+) ) receiving an AHCT were compared to 4688 patients without prior CNS lymphoma (CNS(-) ). There were significant baseline differences between the cohorts. CNS(+) patients were more likely to be younger, have lower performance scores, higher age-adjusted international prognostic index scores, more advanced disease stage at diagnosis, more aggressive histology, more sites of extranodal disease, and a shorter interval between diagnosis and AHCT. However, no statistically significant differences were identified between the two gr

SUBMITTER: Maziarz RT 

PROVIDER: S-EPMC3766698 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature