Rare genetic variants and treatment response: sample size and analysis issues.

ABSTRACT: Incorporating information about common genetic variants may help improve the design and analysis of clinical trials. For example, if genes impact response to treatment, one can pregenotype potential participants to screen out genetically determined nonresponders and substantially reduce the sample size and duration of a trial. Genetic associations with response to treatment are generally much larger than those observed for development of common diseases, as highlighted here by findings from genome-wide association studies. With the development and decreasing cost of next generation sequencing, more extensive genetic information - including rare variants - is becoming available on individuals treated with drugs and other therapies. We can use this information to evaluate whether rare varian

SUBMITTER: Witte JS 

PROVIDER: S-EPMC3766744 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature