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Lewis base directed cycloaddition reactions of 2-pyrones and alkynylaluminum reagents.

ABSTRACT: In situ generated alkynylaluminum reagents have been utilized in a [4 + 2] cycloaddition with 2-pyrones bearing a Lewis basic donor. The reactions proceed at or below room temperature and with complete regiocontrol. This one-pot method affords diversely substituted aromatic compounds under very mild conditions.

SUBMITTER: Crepin DF

PROVIDER: S-EPMC3766945 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Lewis base directed cycloaddition reactions of 2-pyrones and alkynylaluminum reagents.

Crépin Damien F DF Harrity Joseph P A JP

Organic letters 20130805 16

In situ generated alkynylaluminum reagents have been utilized in a [4 + 2] cycloaddition with 2-pyrones bearing a Lewis basic donor. The reactions proceed at or below room temperature and with complete regiocontrol. This one-pot method affords diversely substituted aromatic compounds under very mild conditions. ...[more]

PMID: 23915340

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