Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

ABSTRACT:

Background

Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.

Methods

We analyzed the genomes of 200 clinically annotated adult cases of de novo AML, using either whole-genome sequencing (50 cases) or whole-exome sequencing (150 cases), along with RNA and microRNA sequencing and DNA-methylation analysis.

Results

AML genomes have fewer mutations than most other adult cancers, with an average of only 13 mutations found in genes. Of these, an average of 5 are in genes that are recurrently mutated in AML. A total of 23 genes were significantly mutated, and another 237 were mutated in two or more samples. Nearly all samples had at leas

SUBMITTER: Cancer Genome Atlas Research Network 

PROVIDER: S-EPMC3767041 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature