Ontology highlight
ABSTRACT:
SUBMITTER: Pedersen BS
PROVIDER: S-EPMC3767172 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Pedersen Brent S BS Konstantinopoulos Panagiotis A PA Spillman Monique A MA De Subhajyoti S
Genes, chromosomes & cancer 20130528 9
Loss of heterozygosity (LOH) is a common type of genomic alterations in ovarian cancer. Analyzing 74,415 copy neutral LOH events in 513 serous ovarian adenocarcinomas samples from the Cancer Genome Atlas, we report that the frequency of LOH events increases with age. Similar trend is observed for LOH involving chromosome 17, which is frequently implicated in ovarian cancer. The results are consistent when we analyze data from the Boston high-grade serous cancer cohort. We further show that germ ...[more]