Synthesis, Characterization, and BSA Binding Studies of Some New Benzamides Related to Schiff Base.

ABSTRACT: Condensation of amine 1 with aldehyde 2 gives Schiff base, N-(4-((benzofuran-2-ylmethylene) amino)phenyl)acetamide 3. Schiff base on N-acylation with different substituted acid chlorides in the presence of triethylamine gives the corresponding benzamides, N-acetyl-N-(4-((benzofuran-2-ylmethylene)amino)phenyl)substitutedbenzamide (NABP) 5a-j. The structures of newly synthesized compounds were characterized by elemental analysis, (1)H NMR, (13)C NMR FT-IR, and mass spectral studies. Compounds 3 and 5a-j have been screened for their antimicrobial activity using the disc diffusion and minimum inhibitory concentration (MIC) method against the selected bacterial and fungal strain. Compounds 5a, 5e, 5g, and 5h were found to be more active against all tested strains. The antioxidant properties wer

SUBMITTER: Prashanth MK 

PROVIDER: S-EPMC3767324 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature