Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction: a community-based study.

ABSTRACT:

Background

Patients with heart failure and preserved ejection fraction (HFpEF) display increased adiposity and multiple comorbidities, factors that in themselves may influence cardiovascular structure and function. This has sparked debate as to whether HFpEF represents a distinct disease or an amalgamation of comorbidities. We hypothesized that fundamental cardiovascular structural and functional alterations are characteristic of HFpEF, even after accounting for body size and comorbidities.

Methods and results

Comorbidity-adjusted cardiovascular structural and functional parameters scaled to independently generated and age-appropriate allometric powers were compared in community-based cohorts of HFpEF patients (n=386) and age/sex-matched healthy n=193 and hypertensive, n=386

SUBMITTER: Mohammed SF 

PROVIDER: S-EPMC3767407 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature