Dynamic proteomics of nucleus accumbens in response to acute psychological stress in environmentally enriched and isolated rats.

ABSTRACT: Our prior research has shown that environmental enrichment (i.e. rats reared in an environment with novel objects, social contact with conspecifics) produces a protective antidepressant-like phenotype in rats and decreases neurobiological effects of acute psychological stress. Although CREB activity has been identified as a major player, the downstream molecular mechanisms remain largely unexplored. Thus, the current study investigates proteomic differences in the accumbens of rats raised in an enriched condition (EC) versus those raised in an isolated control condition (IC) under basal conditions and after 30 min of acute restraint stress. Results showed that under basal conditions, EC rats generally expressed less mitochondria-related proteins, particularly those involved in TCA cycle an

SUBMITTER: Fan X 

PROVIDER: S-EPMC3767735 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature