DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk: a meta-analysis.

ABSTRACT:

Background and objective

The X-ray repair cross-complementing group 1 (XRCC1) protein plays a crucial role in base excision repair (BER) pathway by acting as a scaffold for other BER enzymes. Variants in the XRCC1 gene might alter protein structure or function or create alternatively spliced proteins which may influence BER efficiency and hence affect individual susceptibility to bladder cancer. Recent epidemiological studies have shown inconsistent associations between these polymorphisms and bladder cancer. To clarify the situation, a comprehensive meta-analysis of all available studies was performed in this study.

Methods

PubMed, EMBASE, and Chinese Biomedical Literature database (CBM) databases have been systematically searched to identify all relevant studies for the pe

SUBMITTER: Li S 

PROVIDER: S-EPMC3767803 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature